Application and Challenges of Signal Processing Techniques for Lamb Waves Structural Integrity Evaluation: Part A-Lamb Waves Signals Emitting and Optimization Techniques

Lamb waves have been widely studied in structural integrity evaluation during the past decades with their low-attenuation and multi-defects sensitive nature. The performance of the evaluation has close relationship with the vibration property and the frequency of Lamb waves signals. Influenced by the nature of Lamb waves and the environment, the received signals may be difficult to interpret that limits the performance of the detection. So pure Lamb waves mode emitting and high-resolution signals acquisition play important roles in Lamb waves structural integrity evaluation. In this chapter, the basic theory of Lamb waves nature and some environment factors that should be considered in structural integrity evaluation are introduced. Three kinds of typical transduces used for specific Lamb waves mode emitting and sensing are briefly introduced. Then the development of techniques to improve the interpretability of signals are discussed, including the waveform modulation techniques, multi-scale analysis techniques and the temperature effect compensation techniques are summarized

Application and Challenges of Signal Processing Techniques for Lamb Waves Structural Integrity Evaluation: Part B-Defects Imaging and Recognition Techniques

The wavefield of Lamb waves is yielded by the feature of plate-like structures. And many defects imaging techniques and intelligent recognition algorithms have been developed for defects location, sizing and recognition through analyzing the parameters of received Lamb waves signals including the arrival time, attenuation, amplitude and phase, etc. In this chapter, we give a briefly review about the defects imaging techniques and the intelligent recognition algorithms. Considering the available parameters of Lamb waves signals and the setting of detection/monitoring systems, we roughly divide the defect location and sizing techniques into four categories, including the sparse array imaging techniques, the tomography techniques, the compact array techniques, and full wavefield imaging techniques. The principle of them is introduced. Meanwhile, the intelligent recognition techniques based on various of intelligent recognition algorithms that have been widely used to analyze Lamb waves signals in the research of defect recognition are reviewed, including the support vector machine, Bayesian methodology, and the neural networks

Simulation of an Electromagnetic Acoustic Transducer Array by Using Analytical Method and FDTD

Previously, we developed a method based on FEM and FDTD for the study of an Electromagnetic Acoustic Transducer Array (EMAT). This paper presents a new analytical solution to the eddy current problem for the meander coil used in an EMAT, which is adapted from the classic Deeds and Dodd solution originally intended for circular coils. The analytical solution resulting from this novel adaptation exploits the large radius extrapolation and shows several advantages over the finite element method (FEM), especially in the higher frequency regime. The calculated Lorentz force density from the analytical EM solver is then coupled to the ultrasonic simulations, which exploit the finite-difference time-domain (FDTD) method to describe the propagation of ultrasound waves, in particular for Rayleigh waves. Radiation pattern obtained with Hilbert transform on time-domain waveforms is proposed to characterise the sensor in terms of its beam directivity and field distribution along the steering angle, which can produce performance parameters for an EMAT array, facilitating the optimum design of such sensors

Stimulated thyroglobulin and pre-ablation antithyroglobulin antibody products can predict the response to radioiodine therapy of TgAb-positive differentiated thyroid cancer patients: a retrospective study

ObjectiveWe aimed to explore the predictive value of stimulated thyroglobulin (sTg) and pre-ablation antithyroglobulin (pa-TgAb) products for the effect of radioiodine therapy (RAIT) on TgAb-positive differentiated thyroid cancer (DTC) patients.MethodsIn this study, we enrolled 265 patients with TgAb-positive DTC who underwent RAIT after total thyroidectomy (TT). Based on the last follow-up result, the patients were divided into two groups: the excellent response (ER) group and the non-excellent response (NER) group. We analyzed the factors related to the effect of RAIT.ResultsThe ER group consisted of 197 patients. The NER group consisted of 68 patients. For the univariate analysis, we found that the maximal tumor diameter, whether with extrathyroidal extension (ETE), bilateral or unilateral primary lesion, multifocality, preoperative TgAb (preop-TgAb), pa-TgAb, sTg × pa-TgAb, initial RAIT dose, N stage, and surgical extent (modified radical neck dissection or not), showed significant differences between the ER group and NER group (all p-values <0.05). The receiver operating characteristic (ROC) curves showed that the cutoff value was 724.25 IU/ml, 424.00 IU/ml, and 59.73 for preop-TgAb, pa-TgAb, and sTg × pa-TgAb, respectively. The multivariate logistic regression analysis results indicated that pa-TgAb, sTg × pa-TgAb, initial RAIT dose, and N stage were independent risk factors for NER (all p-values <0.05). For the Kaplan–Meier analysis of disease-free survival (DFS), the median DFS of the patients with sTg × pa-TgAb < 59.73 and initial RAIT dose ≤ 100 mCi was significantly longer than that of the patients with sTg × pa-TgAb ≥ 59.73 (50.27 months vs. 48.59 months, p = 0.041) and initial RAIT dose >100 mCi (50.50 months vs. 38.00 months, p = 0.030).ConclusionWe found the sTg and pa-TgAb conducts is a good predictor of the efficacy of RAIT in TgAb-positive DTC patients. It can play a very positive and important role in optimizing treatment, improving prognosis, and reducing the burden of patients

Cancerous Inhibitor of PP2A Silencing Inhibits Proliferation and Promotes Apoptosis in Human Multiple Myeloma Cells

Multiple myeloma is the second most prevalent type of blood cancer, representing approximately 1% of all cancers and 2% of all cancer deaths. There is therefore a strong need to identify critical targets in multiple myeloma neoplasia and progression. Cancerous inhibitor of PP2A (CIP2A) is a human oncoprotein that regulates cancer cell viability and anchorage-independent growth and induces apoptosis. The present study investigated CIP2A function in the human multiple myeloma cell lines RPMI-8226 and NCI-H929 to determine whether it can serve as a potential therapeutic target. CIP2A was silenced in the cells by transfection of short interfering RNA and cell proliferation and apoptosis were evaluated by a tetrazolium salt-based assay and flow cytometry, respectively. CIP2A knockdown inhibited proliferation and induced apoptosis in RPMI-8226 and NCI-H929 cells and decreased the phosphorylation of phosphoinositide 3-kinase (PI3K) p85, AKT1, and mammalian target of rapamycin (mTOR) without affecting total protein levels. Treatment of CIP2A-depletion cells with insulin-like growth factor 1 decreased the effects of CIP2A inhibition on cell viability and apoptosis. These results indicate that CIP2A modulates myeloma cell proliferation and apoptosis via PI3K/AKT/mTOR signaling and suggest that it can potentially serve as a drug target for the treatment of multiple myeloma

A pseudo – 3D model for Electromagnetic Acoustic Transducers (EMATs)

Previous methods for modelling Rayleigh waves produced by a meander-line-coil electromagnetic acoustic transducer (EMAT) consisted mostly of two-dimensional (2D) simulations that focussed on the vertical plane of the material. This paper presents a pseudo-three-dimensional (3D) model that extends the simulation space to both vertical and horizontal planes. For the vertical plane, we combines analytical and finite-difference time-domain (FDTD) methods to model Rayleigh waves’ propagation within an aluminium plate and their scattering behaviours by cracks. For the horizontal surface plane, we employ an analytical method to investigate the radiation pattern of Rayleigh waves at various depths. The experimental results suggest that the models and the modelling techniques are valid